<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019b2d43-b541-76c1-9ac7-66080009875a,g:fdbb8d91-a928-4cc5-8de5-4ffce2002203-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.globusmedical.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUnaudited" xlink:type="simple" xlink:href="gmed-20260331.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETSUnaudited"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019b2d43-b6a3-7407-ae15-aab5ea710fb9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019b2d43-b6a3-72d2-9fdb-e03ce4bb8cb7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019b2d43-b6a3-7407-ae15-aab5ea710fb9" xlink:to="loc_us-gaap_AssetsCurrent_019b2d43-b6a3-72d2-9fdb-e03ce4bb8cb7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019b2d43-b6a3-74c8-84e8-8c45960302a4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019b2d43-b6a3-7407-ae15-aab5ea710fb9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019b2d43-b6a3-74c8-84e8-8c45960302a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019b2d43-b6a3-75fb-ad9b-9e7f5f38cb27" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019b2d43-b6a3-7407-ae15-aab5ea710fb9" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_019b2d43-b6a3-75fb-ad9b-9e7f5f38cb27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_019b2d43-b6a3-766d-b816-d2df8722ccb3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019b2d43-b6a3-7407-ae15-aab5ea710fb9" xlink:to="loc_us-gaap_Goodwill_019b2d43-b6a3-766d-b816-d2df8722ccb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019b2d43-b6a3-7826-8fff-2b1d82769cbd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019b2d43-b6a3-7407-ae15-aab5ea710fb9" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019b2d43-b6a3-7826-8fff-2b1d82769cbd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_019b2d43-b6a3-75f4-9210-f1e3cf499b92" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019b2d43-b6a3-7407-ae15-aab5ea710fb9" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_019b2d43-b6a3-75f4-9210-f1e3cf499b92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesNoncurrent_019b2d43-b6a3-72a9-a0f4-e89ef5105d4d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MarketableSecuritiesNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019b2d43-b6a3-7407-ae15-aab5ea710fb9" xlink:to="loc_us-gaap_MarketableSecuritiesNoncurrent_019b2d43-b6a3-72a9-a0f4-e89ef5105d4d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019b2d43-b6a3-7795-a508-28a8df73c96a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019b2d43-b6a3-7407-ae15-aab5ea710fb9" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019b2d43-b6a3-7795-a508-28a8df73c96a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019b2d43-b6a3-71f8-9e23-77dc837ea96c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019b2d43-b6a3-77f5-bb03-a49a57dc0dd2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019b2d43-b6a3-71f8-9e23-77dc837ea96c" xlink:to="loc_us-gaap_LiabilitiesCurrent_019b2d43-b6a3-77f5-bb03-a49a57dc0dd2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_BusinessAcquisitionLiabilitiesNoncurrent_019b2d43-b6a3-7c2f-ab8f-d051c7edd0b3" xlink:href="gmed-20260331.xsd#gmed_BusinessAcquisitionLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019b2d43-b6a3-71f8-9e23-77dc837ea96c" xlink:to="loc_gmed_BusinessAcquisitionLiabilitiesNoncurrent_019b2d43-b6a3-7c2f-ab8f-d051c7edd0b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndOtherTaxLiabilitiesNoncurrent_019b2d43-b6a3-7d14-91a3-6b6077e1913d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxesAndOtherTaxLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019b2d43-b6a3-71f8-9e23-77dc837ea96c" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndOtherTaxLiabilitiesNoncurrent_019b2d43-b6a3-7d14-91a3-6b6077e1913d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019b2d43-b6a3-7067-b045-9e01a34a9bf8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019b2d43-b6a3-71f8-9e23-77dc837ea96c" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019b2d43-b6a3-7067-b045-9e01a34a9bf8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019b2d43-b6a3-70df-bb20-54171e8298dc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019b2d43-b6a3-71f8-9e23-77dc837ea96c" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019b2d43-b6a3-70df-bb20-54171e8298dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019b2d43-b6a3-7731-a510-222602a00eee" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019b2d43-b6a3-7849-8ff4-5f3067a4b4d4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019b2d43-b6a3-7731-a510-222602a00eee" xlink:to="loc_us-gaap_StockholdersEquity_019b2d43-b6a3-7849-8ff4-5f3067a4b4d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019b2d43-b6a3-7529-bf70-d44ee9b1fe98" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019b2d43-b6a3-7731-a510-222602a00eee" xlink:to="loc_us-gaap_Liabilities_019b2d43-b6a3-7529-bf70-d44ee9b1fe98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019d6b88-c5fe-7a66-8ef0-2797a65ae9d0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019b2d43-b6a3-7731-a510-222602a00eee" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019d6b88-c5fe-7a66-8ef0-2797a65ae9d0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019b2d43-b6a3-72d2-97d6-b515c46481f4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019b2d43-b6a3-7173-ac26-c015a32cf4d1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019b2d43-b6a3-72d2-97d6-b515c46481f4" xlink:to="loc_us-gaap_AccountsPayableCurrent_019b2d43-b6a3-7173-ac26-c015a32cf4d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019b2d43-b6a3-7f20-a191-1e57bf7ac8b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019b2d43-b6a3-72d2-97d6-b515c46481f4" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019b2d43-b6a3-7f20-a191-1e57bf7ac8b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_019b2d43-b6a3-7734-9462-ec7b9a3621e0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019b2d43-b6a3-72d2-97d6-b515c46481f4" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_019b2d43-b6a3-7734-9462-ec7b9a3621e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_BusinessAcquisitionLiabilitiesCurrent_019b2d43-b6a3-7cb0-b9fb-04f1aad9f7ba" xlink:href="gmed-20260331.xsd#gmed_BusinessAcquisitionLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019b2d43-b6a3-72d2-97d6-b515c46481f4" xlink:to="loc_gmed_BusinessAcquisitionLiabilitiesCurrent_019b2d43-b6a3-7cb0-b9fb-04f1aad9f7ba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019b2d43-b6a3-7df7-9437-48ae9555b2aa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019b2d43-b6a3-72d2-97d6-b515c46481f4" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019b2d43-b6a3-7df7-9437-48ae9555b2aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019b2d43-b6a3-7358-ad4f-e19908d51b3e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019b2d43-b6a3-72d2-97d6-b515c46481f4" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019b2d43-b6a3-7358-ad4f-e19908d51b3e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019b2d43-b6a3-7a31-8aee-6ec46d9a8e69" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019b2d43-b6a3-70d5-94a0-b3234403de51" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019b2d43-b6a3-7a31-8aee-6ec46d9a8e69" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019b2d43-b6a3-70d5-94a0-b3234403de51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_019b2d43-b6a3-7266-b7cc-c5591678656d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019b2d43-b6a3-7a31-8aee-6ec46d9a8e69" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_019b2d43-b6a3-7266-b7cc-c5591678656d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019b2d43-b6a3-7ef4-b70f-2d8a7b1ae736" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019b2d43-b6a3-7a31-8aee-6ec46d9a8e69" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019b2d43-b6a3-7ef4-b70f-2d8a7b1ae736" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019b2d43-b6a3-70f9-a77b-ea3f99beb05a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019b2d43-b6a3-7a31-8aee-6ec46d9a8e69" xlink:to="loc_us-gaap_InventoryNet_019b2d43-b6a3-70f9-a77b-ea3f99beb05a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019b2d43-b6a3-72a4-a5c5-aeac9c8173b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019b2d43-b6a3-7a31-8aee-6ec46d9a8e69" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019b2d43-b6a3-72a4-a5c5-aeac9c8173b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesReceivable_019b2d43-b6a3-7da9-acab-71698a74805e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxesReceivable"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019b2d43-b6a3-7a31-8aee-6ec46d9a8e69" xlink:to="loc_us-gaap_IncomeTaxesReceivable_019b2d43-b6a3-7da9-acab-71698a74805e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019b2d43-b6a3-79bc-8595-346a2020a760" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019b2d43-b6a3-71b5-818e-7516eec2c818" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019b2d43-b6a3-79bc-8595-346a2020a760" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019b2d43-b6a3-71b5-818e-7516eec2c818" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019b2d43-b6a3-7321-bb02-e41d2654593b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019b2d43-b6a3-79bc-8595-346a2020a760" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019b2d43-b6a3-7321-bb02-e41d2654593b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019b2d43-b6a3-7160-af3b-781063d0171a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019b2d43-b6a3-79bc-8595-346a2020a760" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019b2d43-b6a3-7160-af3b-781063d0171a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019b2d43-b6a3-7ba3-af65-a5b1b1bc5075" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019b2d43-b6a3-79bc-8595-346a2020a760" xlink:to="loc_us-gaap_CommonStockValue_019b2d43-b6a3-7ba3-af65-a5b1b1bc5075" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMEUnaudited" xlink:type="simple" xlink:href="gmed-20260331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMEUnaudited"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOMEUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019b2d43-b6a3-7b97-9e4b-e3db5b8e98b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019b2d43-b6a3-7f1f-9cf7-64fd329c4d23" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019b2d43-b6a3-7b97-9e4b-e3db5b8e98b9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_019b2d43-b6a3-7f1f-9cf7-64fd329c4d23" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019b2d43-b6a3-73cc-b451-f25450dfed68" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019b2d43-b6a3-7b97-9e4b-e3db5b8e98b9" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_019b2d43-b6a3-73cc-b451-f25450dfed68" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019b2d43-b6a3-7774-aad3-0cdc2e06a01c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019b2d43-b6a3-7172-86cc-d748d2d69ca7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019b2d43-b6a3-7774-aad3-0cdc2e06a01c" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019b2d43-b6a3-7172-86cc-d748d2d69ca7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019b2d43-b6a3-7624-ba9a-9ce18cbbee85" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019b2d43-b6a3-7774-aad3-0cdc2e06a01c" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019b2d43-b6a3-7624-ba9a-9ce18cbbee85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationBargainPurchaseGainRecognizedAmount_019b2d43-b6a3-7708-bad2-212fefb3d089" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationBargainPurchaseGainRecognizedAmount"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019b2d43-b6a3-7774-aad3-0cdc2e06a01c" xlink:to="loc_us-gaap_BusinessCombinationBargainPurchaseGainRecognizedAmount_019b2d43-b6a3-7708-bad2-212fefb3d089" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019b2d43-b6a3-777d-b172-f9ef8ced850a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019b2d43-b6a3-7774-aad3-0cdc2e06a01c" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019b2d43-b6a3-777d-b172-f9ef8ced850a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019b2d43-b6a3-745b-910f-0cfcbaef77f0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019b2d43-b6a3-7aac-8157-b6e313b8e166" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019b2d43-b6a3-745b-910f-0cfcbaef77f0" xlink:to="loc_us-gaap_NetIncomeLoss_019b2d43-b6a3-7aac-8157-b6e313b8e166" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019b2d43-b6a3-737e-9422-5fee53aa9fa1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019b2d43-b6a3-745b-910f-0cfcbaef77f0" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019b2d43-b6a3-737e-9422-5fee53aa9fa1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019b2d43-b6a3-7d60-9a97-9fe05e8e81e2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019b2d43-b6a3-7fa9-a8c2-44ffd6524470" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019b2d43-b6a3-7d60-9a97-9fe05e8e81e2" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019b2d43-b6a3-7fa9-a8c2-44ffd6524470" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019b2d43-b6a3-79b8-b502-c5648e5d0f6b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019b2d43-b6a3-7d60-9a97-9fe05e8e81e2" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019b2d43-b6a3-79b8-b502-c5648e5d0f6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019b2d43-b6a3-761c-afcd-c60c3e8e35c1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019b2d43-b6a3-75f0-9d4f-184db701cc2e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019b2d43-b6a3-761c-afcd-c60c3e8e35c1" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019b2d43-b6a3-75f0-9d4f-184db701cc2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019b2d43-b6a3-7739-9a75-0251b704d6d6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019b2d43-b6a3-761c-afcd-c60c3e8e35c1" xlink:to="loc_us-gaap_Revenues_019b2d43-b6a3-7739-9a75-0251b704d6d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019b2d43-b6a3-7c71-bf92-72290f929d63" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019b2d43-b6a3-761c-afcd-c60c3e8e35c1" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019b2d43-b6a3-7c71-bf92-72290f929d63" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019b2d43-b6a3-7e95-bba8-25289862256f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019b2d43-b6a3-761c-afcd-c60c3e8e35c1" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_019b2d43-b6a3-7e95-bba8-25289862256f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019b2d43-b6a3-7397-a22b-8cbc10eccb4e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019b2d43-b6a3-761c-afcd-c60c3e8e35c1" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019b2d43-b6a3-7397-a22b-8cbc10eccb4e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_019b2d43-b6a3-72c9-b8ee-e857e13cf3a0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019b2d43-b6a3-761c-afcd-c60c3e8e35c1" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_019b2d43-b6a3-72c9-b8ee-e857e13cf3a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCosts_019b2d43-b6a3-78ea-b57e-13b2ca42d281" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestructuringCosts"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019b2d43-b6a3-761c-afcd-c60c3e8e35c1" xlink:to="loc_us-gaap_RestructuringCosts_019b2d43-b6a3-78ea-b57e-13b2ca42d281" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019b2d43-b6a3-7cc5-b9e3-0561e787d097" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019b2d43-b6a3-7bb2-9bc2-a9828633c1b9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019b2d43-b6a3-7cc5-b9e3-0561e787d097" xlink:to="loc_us-gaap_OperatingIncomeLoss_019b2d43-b6a3-7bb2-9bc2-a9828633c1b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019b2d43-b6a3-72c4-8bc8-387481139066" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019b2d43-b6a3-7cc5-b9e3-0561e787d097" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019b2d43-b6a3-72c4-8bc8-387481139066" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="simple" xlink:href="gmed-20260331.xsd#CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/CONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWSUnaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019b2d43-b6a3-78b6-91f0-a03f9884b4bd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_PaymentOfBusinessAcquisitionLiabilities_019b2d43-b6a3-73c5-aa40-0b655c44a315" xlink:href="gmed-20260331.xsd#gmed_PaymentOfBusinessAcquisitionLiabilities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019b2d43-b6a3-78b6-91f0-a03f9884b4bd" xlink:to="loc_gmed_PaymentOfBusinessAcquisitionLiabilities_019b2d43-b6a3-73c5-aa40-0b655c44a315" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_019b2d43-b6a3-7d55-ad39-f8b181ad6679" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019b2d43-b6a3-78b6-91f0-a03f9884b4bd" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_019b2d43-b6a3-7d55-ad39-f8b181ad6679" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019b2d43-b6a3-70ea-9f47-99332c575d55" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019b2d43-b6a3-78b6-91f0-a03f9884b4bd" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019b2d43-b6a3-70ea-9f47-99332c575d55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019b2d43-b6a3-7580-a8a0-0ef0ff476e8a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019b2d43-b6a3-78b6-91f0-a03f9884b4bd" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_019b2d43-b6a3-7580-a8a0-0ef0ff476e8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfSeniorDebt_019b2d43-b6a3-7340-a49e-4778efeb7986" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RepaymentsOfSeniorDebt"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019b2d43-b6a3-78b6-91f0-a03f9884b4bd" xlink:to="loc_us-gaap_RepaymentsOfSeniorDebt_019b2d43-b6a3-7340-a49e-4778efeb7986" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationBargainPurchaseGainRecognizedAmount_019b2d43-b6a3-7cab-a8a0-bb573040082e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationBargainPurchaseGainRecognizedAmount"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_BusinessCombinationBargainPurchaseGainRecognizedAmount_019b2d43-b6a3-7cab-a8a0-bb573040082e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentForContingentConsiderationLiabilityOperatingActivities_019b2d43-b6a3-7dd9-bcae-ab9263a1954e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentForContingentConsiderationLiabilityOperatingActivities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_PaymentForContingentConsiderationLiabilityOperatingActivities_019b2d43-b6a3-7dd9-bcae-ab9263a1954e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019b2d43-b6a3-7620-b78e-7b5226a38166" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_NetIncomeLoss_019b2d43-b6a3-7620-b78e-7b5226a38166" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019b2d43-b6a3-7781-b170-05ac4f3dc2bb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019b2d43-b6a3-7781-b170-05ac4f3dc2bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_019b2d43-b6a3-7dc5-a95e-8d7e5c1070d9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_InventoryWriteDown_019b2d43-b6a3-7dc5-a95e-8d7e5c1070d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019b2d43-b6a3-7fc5-82f9-5dfb2e522567" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_ShareBasedCompensation_019b2d43-b6a3-7fc5-82f9-5dfb2e522567" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_019b2d43-b6a3-7983-bf46-96678e313f7e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProvisionForDoubtfulAccounts"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_019b2d43-b6a3-7983-bf46-96678e313f7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_AmortizationOfAcquisitionAccountingFairValueStepUp_019b2d43-b6a3-7b36-9801-0beba27fd2c9" xlink:href="gmed-20260331.xsd#gmed_AmortizationOfAcquisitionAccountingFairValueStepUp"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_gmed_AmortizationOfAcquisitionAccountingFairValueStepUp_019b2d43-b6a3-7b36-9801-0beba27fd2c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_019b2d43-b6a3-77e8-a106-20faad2e4c92" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_019b2d43-b6a3-77e8-a106-20faad2e4c92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_019b2d43-b6a3-71f2-91b1-cb75b57bf3ec" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxesAndTaxCredits"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndTaxCredits_019b2d43-b6a3-71f2-91b1-cb75b57bf3ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets1_019b2d43-b6a3-7baf-9f7f-cc0c3fa23b29" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_GainLossOnDispositionOfAssets1"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets1_019b2d43-b6a3-7baf-9f7f-cc0c3fa23b29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019b2d43-b6a3-7f30-a980-518b1be669f3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019b2d43-b6a3-7f30-a980-518b1be669f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019b2d43-b6a3-7324-bf39-93e4cebd69c4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019b2d43-b6a3-7324-bf39-93e4cebd69c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019b2d43-b6a3-7b33-b1d5-f13e585c68d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="14" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019b2d43-b6a3-7b33-b1d5-f13e585c68d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019b2d43-b6a3-72ea-ba7c-3065aa28966c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019b2d43-b6a3-72ea-ba7c-3065aa28966c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_019b2d43-b6a3-79a6-82ca-38011404d93c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_019b2d43-b6a3-79a6-82ca-38011404d93c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_019b2d43-b6a3-7b60-81dd-07b707f4cbb3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedIncomeTaxesPayable_019b2d43-b6a3-7b60-81dd-07b707f4cbb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_NetGainLossFromForeignCurrencyAdjustment_019b2d43-b6a3-79a8-b869-4cc0e319710f" xlink:href="gmed-20260331.xsd#gmed_NetGainLossFromForeignCurrencyAdjustment"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7154-98a9-75509e36d392" xlink:to="loc_gmed_NetGainLossFromForeignCurrencyAdjustment_019b2d43-b6a3-79a8-b869-4cc0e319710f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019b2d43-b6a3-75c5-8ab7-e393db5020a7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7e7b-8cfb-36a433a43982" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019b2d43-b6a3-75c5-8ab7-e393db5020a7" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019b2d43-b6a3-7e7b-8cfb-36a433a43982" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019b2d43-b6a3-7ba1-b775-c5f2e6e22723" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019b2d43-b6a3-75c5-8ab7-e393db5020a7" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019b2d43-b6a3-7ba1-b775-c5f2e6e22723" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019b2d43-b6a3-7610-abfe-0c7cca1d39b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019b2d43-b6a3-75c5-8ab7-e393db5020a7" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019b2d43-b6a3-7610-abfe-0c7cca1d39b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019b2d43-b6a3-7a2b-962a-4704c3df2227" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_019b2d43-b6a3-75c5-8ab7-e393db5020a7" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_019b2d43-b6a3-7a2b-962a-4704c3df2227" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019b2d43-b6a3-7d2b-987a-e0dc1bef9be0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019df99e-9f93-7acd-a79c-782fff9bf047" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019b2d43-b6a3-7d2b-987a-e0dc1bef9be0" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_019df99e-9f93-7acd-a79c-782fff9bf047" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_019b2d43-b6a3-7bf8-a20c-f896bd7747be" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019b2d43-b6a3-7d2b-987a-e0dc1bef9be0" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_019b2d43-b6a3-7bf8-a20c-f896bd7747be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019df99f-6dfe-74bc-81f4-f763aacd9e13" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019b2d43-b6a3-7d2b-987a-e0dc1bef9be0" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019df99f-6dfe-74bc-81f4-f763aacd9e13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019df9a0-5ea6-7454-985e-6d23d3d5c61e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019b2d43-b6a3-7d2b-987a-e0dc1bef9be0" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_019df9a0-5ea6-7454-985e-6d23d3d5c61e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/ASSETACQUISITIONSANDBUSINESSCOMBINATIONSScheduleofAggregateConsiderationofMergerDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#ASSETACQUISITIONSANDBUSINESSCOMBINATIONSScheduleofAggregateConsiderationofMergerDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/ASSETACQUISITIONSANDBUSINESSCOMBINATIONSScheduleofAggregateConsiderationofMergerDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_019d1b1b-e2d1-78ab-b1aa-fa11b6979807" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_019d1b1b-e2d1-76e6-9c50-31608a834e21" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_019d1b1b-e2d1-78ab-b1aa-fa11b6979807" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_019d1b1b-e2d1-76e6-9c50-31608a834e21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_RepaymentOfTermLoansWarrantsAndOtherTransactionCosts_019d1b1b-e2d1-7ef2-a5f0-59471e29d8fd" xlink:href="gmed-20260331.xsd#gmed_RepaymentOfTermLoansWarrantsAndOtherTransactionCosts"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_019d1b1b-e2d1-78ab-b1aa-fa11b6979807" xlink:to="loc_gmed_RepaymentOfTermLoansWarrantsAndOtherTransactionCosts_019d1b1b-e2d1-7ef2-a5f0-59471e29d8fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_BusinessCombinationFairValueOfCashSettledEquityAwards_019d1b1b-e2d1-717c-afca-c5c00f775c87" xlink:href="gmed-20260331.xsd#gmed_BusinessCombinationFairValueOfCashSettledEquityAwards"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_019d1b1b-e2d1-78ab-b1aa-fa11b6979807" xlink:to="loc_gmed_BusinessCombinationFairValueOfCashSettledEquityAwards_019d1b1b-e2d1-717c-afca-c5c00f775c87" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/ASSETACQUISITIONSANDBUSINESSCOMBINATIONSScheduleofPreliminaryPurchasePriceDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#ASSETACQUISITIONSANDBUSINESSCOMBINATIONSScheduleofPreliminaryPurchasePriceDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/ASSETACQUISITIONSANDBUSINESSCOMBINATIONSScheduleofPreliminaryPurchasePriceDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019d1b1b-e2d1-796b-9fa1-0e755812d7cd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiabilities_019d1b1b-e2d1-741c-b05b-8c959704b16a" xlink:href="gmed-20260331.xsd#gmed_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019d1b1b-e2d1-796b-9fa1-0e755812d7cd" xlink:to="loc_gmed_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseLiabilities_019d1b1b-e2d1-741c-b05b-8c959704b16a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_019d1b1b-e2d1-7c06-a716-2988751cbfb8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019d1b1b-e2d1-796b-9fa1-0e755812d7cd" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_019d1b1b-e2d1-7c06-a716-2988751cbfb8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019d1b1b-e2d1-74d4-8d02-5b8690a902dc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseRightOfUseAssets_019d1b1b-e2d1-7457-88dc-ac6ee4b57e9b" xlink:href="gmed-20260331.xsd#gmed_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseRightOfUseAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019d1b1b-e2d1-74d4-8d02-5b8690a902dc" xlink:to="loc_gmed_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOperatingLeaseRightOfUseAssets_019d1b1b-e2d1-7457-88dc-ac6ee4b57e9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssets_019d1b1b-e2d1-740c-91e5-1224143241c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssets"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019d1b1b-e2d1-74d4-8d02-5b8690a902dc" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxAssets_019d1b1b-e2d1-740c-91e5-1224143241c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsExcludingAccountsReceivableAndInventories_019d1b1b-e2d1-7237-a0ad-c3846b329905" xlink:href="gmed-20260331.xsd#gmed_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsExcludingAccountsReceivableAndInventories"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019d1b1b-e2d1-74d4-8d02-5b8690a902dc" xlink:to="loc_gmed_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsExcludingAccountsReceivableAndInventories_019d1b1b-e2d1-7237-a0ad-c3846b329905" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_019d1b1b-e2d1-7226-a9c7-2344e7eb30b5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019d1b1b-e2d1-74d4-8d02-5b8690a902dc" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_019d1b1b-e2d1-7226-a9c7-2344e7eb30b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_019d1b1b-e2d1-7a0e-a791-708e809cc3fa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019d1b1b-e2d1-74d4-8d02-5b8690a902dc" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_019d1b1b-e2d1-7a0e-a791-708e809cc3fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_019d1b1b-e2d1-70d3-91e5-f5ab5693f23b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019d1b1b-e2d1-74d4-8d02-5b8690a902dc" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_019d1b1b-e2d1-70d3-91e5-f5ab5693f23b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_019d1b1b-e2d1-7bca-b88e-18c5a3713710" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019d1b1b-e2d1-74d4-8d02-5b8690a902dc" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_019d1b1b-e2d1-7bca-b88e-18c5a3713710" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019d1b1b-e2d1-7c4c-b61a-2c40ff65db9f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019d1b1b-e2d1-74d4-8d02-5b8690a902dc" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_019d1b1b-e2d1-7c4c-b61a-2c40ff65db9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019d1b1b-e2d1-788a-a80f-7fa61096c0e9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019d1b1b-e2d1-703c-86f9-2dd69c679e06" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019d1b1b-e2d1-788a-a80f-7fa61096c0e9" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_019d1b1b-e2d1-703c-86f9-2dd69c679e06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019d1b1b-e2d1-72dc-ac2a-c702360cd276" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_019d1b1b-e2d1-788a-a80f-7fa61096c0e9" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_019d1b1b-e2d1-72dc-ac2a-c702360cd276" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/MARKETABLESECURITIESCompositionofMarketableSecuritiesDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#MARKETABLESECURITIESCompositionofMarketableSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/MARKETABLESECURITIESCompositionofMarketableSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostCurrent_019d1a57-9ad5-7975-9486-ec4de2a251a1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedGainBeforeTax_019d1a57-9ad5-7dfe-a712-30e2e25d4007" xlink:href="gmed-20260331.xsd#gmed_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostCurrent_019d1a57-9ad5-7975-9486-ec4de2a251a1" xlink:to="loc_gmed_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedGainBeforeTax_019d1a57-9ad5-7dfe-a712-30e2e25d4007" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedLossBeforeTax_019d1a57-9ad5-7c45-9e6a-595db5e671be" xlink:href="gmed-20260331.xsd#gmed_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostCurrent_019d1a57-9ad5-7975-9486-ec4de2a251a1" xlink:to="loc_gmed_AvailableForSaleDebtSecuritiesCurrentAccumulatedGrossUnrealizedLossBeforeTax_019d1a57-9ad5-7c45-9e6a-595db5e671be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019d1a57-9ad5-7a80-a184-47b17752803d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostCurrent_019d1a57-9ad5-7975-9486-ec4de2a251a1" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019d1a57-9ad5-7a80-a184-47b17752803d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostNoncurrent_019d1a57-9ad5-70fe-a28f-70b8f4718deb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_AvailableForSaleDebtSecuritiesNoncurrentAccumulatedGrossUnrealizedGainBeforeTax_019d1a57-9ad5-79ac-a0a0-0f989a54d130" xlink:href="gmed-20260331.xsd#gmed_AvailableForSaleDebtSecuritiesNoncurrentAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostNoncurrent_019d1a57-9ad5-70fe-a28f-70b8f4718deb" xlink:to="loc_gmed_AvailableForSaleDebtSecuritiesNoncurrentAccumulatedGrossUnrealizedGainBeforeTax_019d1a57-9ad5-79ac-a0a0-0f989a54d130" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_AvailableForSaleDebtSecuritiesNoncurrentAccumulatedGrossUnrealizedLossBeforeTax_019d1a57-9ad5-70f0-afbe-3c50134683ce" xlink:href="gmed-20260331.xsd#gmed_AvailableForSaleDebtSecuritiesNoncurrentAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostNoncurrent_019d1a57-9ad5-70fe-a28f-70b8f4718deb" xlink:to="loc_gmed_AvailableForSaleDebtSecuritiesNoncurrentAccumulatedGrossUnrealizedLossBeforeTax_019d1a57-9ad5-70f0-afbe-3c50134683ce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019d1a57-9ad5-7ded-9035-7da865effb73" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostNoncurrent_019d1a57-9ad5-70fe-a28f-70b8f4718deb" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesNoncurrent_019d1a57-9ad5-7ded-9035-7da865effb73" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/INVENTORIESScheduleofInventoryDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#INVENTORIESScheduleofInventoryDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/INVENTORIESScheduleofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019b2d43-b6a3-7e1a-af83-528c7a11ea22" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_019b2d43-b6a3-75bb-ae94-d58e0a8798a8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryRawMaterials"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019b2d43-b6a3-7e1a-af83-528c7a11ea22" xlink:to="loc_us-gaap_InventoryRawMaterials_019b2d43-b6a3-75bb-ae94-d58e0a8798a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_019b2d43-b6a3-719f-8448-f8716ca379f1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019b2d43-b6a3-7e1a-af83-528c7a11ea22" xlink:to="loc_us-gaap_InventoryWorkInProcess_019b2d43-b6a3-719f-8448-f8716ca379f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019b2d43-b6a3-7e12-98fd-a2c9768b44bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019b2d43-b6a3-7e1a-af83-528c7a11ea22" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019b2d43-b6a3-7e12-98fd-a2c9768b44bc" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/PROPERTYANDEQUIPMENTScheduleofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#PROPERTYANDEQUIPMENTScheduleofPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/PROPERTYANDEQUIPMENTScheduleofPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019b2d43-b6a3-7305-99fc-72331456dc2d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019b2d43-b6a3-7ed0-b2ff-9c3269367b5d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019b2d43-b6a3-7305-99fc-72331456dc2d" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019b2d43-b6a3-7ed0-b2ff-9c3269367b5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019b2d43-b6a3-71a5-b21a-74d0553915f3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019b2d43-b6a3-7305-99fc-72331456dc2d" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019b2d43-b6a3-71a5-b21a-74d0553915f3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofFiniteLivedIntangibleAssetsDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#GOODWILLANDINTANGIBLEASSETSScheduleofFiniteLivedIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofFiniteLivedIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019b2d43-b6a3-78c5-8211-49e532980f31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019b2d43-b6a3-7900-aa8c-ebed5abe9b62" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019b2d43-b6a3-78c5-8211-49e532980f31" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_019b2d43-b6a3-7900-aa8c-ebed5abe9b62" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019b2d43-b6a3-7265-b1ed-e2f3a18272d2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019b2d43-b6a3-78c5-8211-49e532980f31" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_019b2d43-b6a3-7265-b1ed-e2f3a18272d2" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#GOODWILLANDINTANGIBLEASSETSScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/GOODWILLANDINTANGIBLEASSETSScheduleofFiniteLivedIntangibleAssetsFutureAmortizationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019b2d43-b6a3-7a8b-b746-b413671063c4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019b2d43-b6a3-7e95-a48e-41c54b279aad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019b2d43-b6a3-7a8b-b746-b413671063c4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear_019b2d43-b6a3-7e95-a48e-41c54b279aad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019b2d43-b6a3-767a-880e-2206c9953ab9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019b2d43-b6a3-7a8b-b746-b413671063c4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_019b2d43-b6a3-767a-880e-2206c9953ab9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019b2d43-b6a3-7a7f-9d5d-f7e76fb24974" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019b2d43-b6a3-7a8b-b746-b413671063c4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_019b2d43-b6a3-7a7f-9d5d-f7e76fb24974" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019b2d43-b6a3-7d16-8eb3-ad4a36c91911" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019b2d43-b6a3-7a8b-b746-b413671063c4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_019b2d43-b6a3-7d16-8eb3-ad4a36c91911" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearThree_019b2d43-b6a3-78c4-86b3-9cbe0beef288" xlink:href="gmed-20260331.xsd#gmed_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearThree"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_019b2d43-b6a3-7a8b-b746-b413671063c4" xlink:to="loc_gmed_FiniteLivedIntangibleAssetExpectedAmortizationAfterYearThree_019b2d43-b6a3-78c4-86b3-9cbe0beef288" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/ACCRUEDEXPENSESDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#ACCRUEDEXPENSESDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/ACCRUEDEXPENSESDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019d1a82-fbf7-7b40-98ac-c96e8580214b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019d1a82-fbf7-7342-b12b-1a964579327f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019d1a82-fbf7-7b40-98ac-c96e8580214b" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019d1a82-fbf7-7342-b12b-1a964579327f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_AccruedLiabilitiesLegalAndOtherSettlementsAndExpenses_019d1a82-fbf7-7c34-a647-1d2419e9c21f" xlink:href="gmed-20260331.xsd#gmed_AccruedLiabilitiesLegalAndOtherSettlementsAndExpenses"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019d1a82-fbf7-7b40-98ac-c96e8580214b" xlink:to="loc_gmed_AccruedLiabilitiesLegalAndOtherSettlementsAndExpenses_019d1a82-fbf7-7c34-a647-1d2419e9c21f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccrualForTaxesOtherThanIncomeTaxesCurrent_019d1a82-fbf7-74b2-b8f7-d37f346ecadb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccrualForTaxesOtherThanIncomeTaxesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019d1a82-fbf7-7b40-98ac-c96e8580214b" xlink:to="loc_us-gaap_AccrualForTaxesOtherThanIncomeTaxesCurrent_019d1a82-fbf7-74b2-b8f7-d37f346ecadb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrent_019d1a82-fbf7-7fdf-9a7a-96a7dc177c72" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedRoyaltiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019d1a82-fbf7-7b40-98ac-c96e8580214b" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrent_019d1a82-fbf7-7fdf-9a7a-96a7dc177c72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedExchangeFeeRebateCurrent_019d1a82-fbf7-74a6-af5f-c1daa8c7e7f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedExchangeFeeRebateCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019d1a82-fbf7-7b40-98ac-c96e8580214b" xlink:to="loc_us-gaap_AccruedExchangeFeeRebateCurrent_019d1a82-fbf7-74a6-af5f-c1daa8c7e7f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019d1a82-fbf7-7bd1-a87f-ac6045f64104" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019d1a82-fbf7-7b40-98ac-c96e8580214b" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019d1a82-fbf7-7bd1-a87f-ac6045f64104" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/EQUITYScheduleofAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#EQUITYScheduleofAccumulatedOtherComprehensiveIncomeLossDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/EQUITYScheduleofAccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019d1b3e-a19a-7caa-a504-947d9c515d3f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_019d1b3e-a19a-7048-912b-d7774167a2b6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019d1b3e-a19a-7caa-a504-947d9c515d3f" xlink:to="loc_us-gaap_OciBeforeReclassificationsNetOfTaxAttributableToParent_019d1b3e-a19a-7048-912b-d7774167a2b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_019d1b3e-a19a-7961-b6f0-cb8af6e346c7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_019d1b3e-a19a-7caa-a504-947d9c515d3f" xlink:to="loc_us-gaap_ReclassificationFromAociCurrentPeriodNetOfTaxAttributableToParent_019d1b3e-a19a-7961-b6f0-cb8af6e346c7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/EQUITYScheduleofComputationofBasicandDilutedEarningsDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#EQUITYScheduleofComputationofBasicandDilutedEarningsDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/EQUITYScheduleofComputationofBasicandDilutedEarningsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019d1b3e-a19a-77a9-981d-b9de0f814970" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019d1b3e-a19a-798f-aad2-ce7b838fd452" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019d1b3e-a19a-77a9-981d-b9de0f814970" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_019d1b3e-a19a-798f-aad2-ce7b838fd452" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019d1b3e-a19a-71c3-8300-0df6d1f0c2a0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_019d1b3e-a19a-77a9-981d-b9de0f814970" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_019d1b3e-a19a-71c3-8300-0df6d1f0c2a0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/STOCKBASEDAWARDSScheduleofStockbasedCompensationScheduleDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#STOCKBASEDAWARDSScheduleofStockbasedCompensationScheduleDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/STOCKBASEDAWARDSScheduleofStockbasedCompensationScheduleDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_019d1b51-6b2a-70cf-9061-6e2659b1c60d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_019d1b51-6b2a-7c52-8442-35d4183e4b31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_019d1b51-6b2a-70cf-9061-6e2659b1c60d" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_019d1b51-6b2a-7c52-8442-35d4183e4b31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_019d1b51-6b2a-7a9a-ab89-220c97f64953" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardCompensationCost1_019d1b51-6b2a-70cf-9061-6e2659b1c60d" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_019d1b51-6b2a-7a9a-ab89-220c97f64953" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/LEASESScheduleofAmountReportedinCondensedConsolidatedBalanceSheetDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#LEASESScheduleofAmountReportedinCondensedConsolidatedBalanceSheetDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/LEASESScheduleofAmountReportedinCondensedConsolidatedBalanceSheetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_gmed_TotalLeasedAssets_019d1aab-f8ac-729b-9fd0-462fc9b7bbe6" xlink:href="gmed-20260331.xsd#gmed_TotalLeasedAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_019d1aab-f8ac-704d-af27-9229526bb26c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_gmed_TotalLeasedAssets_019d1aab-f8ac-729b-9fd0-462fc9b7bbe6" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_019d1aab-f8ac-704d-af27-9229526bb26c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_019d1aab-f8ac-704e-adde-5b43c5244bb3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_gmed_TotalLeasedAssets_019d1aab-f8ac-729b-9fd0-462fc9b7bbe6" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_019d1aab-f8ac-704e-adde-5b43c5244bb3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_TotalLeaseLiability_019d1aab-f8ac-7f1b-9b0f-6d389a7322f4" xlink:href="gmed-20260331.xsd#gmed_TotalLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_019d1aab-f8ac-77b0-99a3-c845015e9730" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_gmed_TotalLeaseLiability_019d1aab-f8ac-7f1b-9b0f-6d389a7322f4" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_019d1aab-f8ac-77b0-99a3-c845015e9730" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_019d1aab-f8ac-70ab-a52f-9e42bd224a52" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_gmed_TotalLeaseLiability_019d1aab-f8ac-7f1b-9b0f-6d389a7322f4" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_019d1aab-f8ac-70ab-a52f-9e42bd224a52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019d1aab-f8ac-7fd5-86a2-993b78e3515d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_gmed_TotalLeaseLiability_019d1aab-f8ac-7f1b-9b0f-6d389a7322f4" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019d1aab-f8ac-7fd5-86a2-993b78e3515d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019d1aab-f8ac-7784-8c6e-32973eb12c1f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_gmed_TotalLeaseLiability_019d1aab-f8ac-7f1b-9b0f-6d389a7322f4" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019d1aab-f8ac-7784-8c6e-32973eb12c1f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/LEASESScheduleofLeaseExpenseDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#LEASESScheduleofLeaseExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/LEASESScheduleofLeaseExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_019d1aab-f8ac-7c45-a550-bab1590aca61" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseInterestExpense_019d1aab-f8ac-74e1-b2e7-941b54afb260" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseInterestExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019d1aab-f8ac-7c45-a550-bab1590aca61" xlink:to="loc_us-gaap_FinanceLeaseInterestExpense_019d1aab-f8ac-74e1-b2e7-941b54afb260" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_019d1aab-f8ac-766f-ba2a-52fdcbf9dd57" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019d1aab-f8ac-7c45-a550-bab1590aca61" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_019d1aab-f8ac-766f-ba2a-52fdcbf9dd57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_019d1aab-f8ac-7c81-aa53-717db12e97ce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019d1aab-f8ac-7c45-a550-bab1590aca61" xlink:to="loc_us-gaap_OperatingLeaseCost_019d1aab-f8ac-7c81-aa53-717db12e97ce" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/LEASESScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#LEASESScheduleofFutureMinimumLeasePaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/LEASESScheduleofFutureMinimumLeasePaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019d1aab-f8ac-775e-84d9-5f1b2f1b5b2d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_019d1aab-f8ac-7297-b547-53b1033825cd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019d1aab-f8ac-775e-84d9-5f1b2f1b5b2d" xlink:to="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_019d1aab-f8ac-7297-b547-53b1033825cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_019d1aab-f8ac-741b-9429-96cbd048f7d8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019d1aab-f8ac-775e-84d9-5f1b2f1b5b2d" xlink:to="loc_us-gaap_FinanceLeaseLiability_019d1aab-f8ac-741b-9429-96cbd048f7d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_019d1aab-f8ac-7700-8734-d96c9568dbb9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_019d1aab-f8ac-7f8b-8979-6219a47ffe54" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiability_019d1aab-f8ac-7700-8734-d96c9568dbb9" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_019d1aab-f8ac-7f8b-8979-6219a47ffe54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_019d1aab-f8ac-76ee-a383-53baacc40252" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiability_019d1aab-f8ac-7700-8734-d96c9568dbb9" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_019d1aab-f8ac-76ee-a383-53baacc40252" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d1aab-f8ac-7d49-9a47-6b49745143bc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019d1aab-f8ac-7b3b-9cbf-2d73f64d973c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d1aab-f8ac-7d49-9a47-6b49745143bc" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019d1aab-f8ac-7b3b-9cbf-2d73f64d973c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019d1aab-f8ac-710e-9216-2ae9dbdbe65e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d1aab-f8ac-7d49-9a47-6b49745143bc" xlink:to="loc_us-gaap_OperatingLeaseLiability_019d1aab-f8ac-710e-9216-2ae9dbdbe65e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019d1aab-f8ac-7852-a75c-79d9b7676d0b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019d1aab-f8ac-7b75-bafa-04542100ad7e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019d1aab-f8ac-7852-a75c-79d9b7676d0b" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019d1aab-f8ac-7b75-bafa-04542100ad7e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019d1aab-f8ac-7472-b711-266ed63fba3d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019d1aab-f8ac-7852-a75c-79d9b7676d0b" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019d1aab-f8ac-7472-b711-266ed63fba3d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/LEASESScheduleofFutureMinimumLeasePaymentsDetails_1" xlink:type="simple" xlink:href="gmed-20260331.xsd#LEASESScheduleofFutureMinimumLeasePaymentsDetails_1"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/LEASESScheduleofFutureMinimumLeasePaymentsDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d1aab-f8ac-7b17-94f3-8cb1c209a099" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019d1aab-f8ac-7ad3-9501-3ffbb8e404e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d1aab-f8ac-7b17-94f3-8cb1c209a099" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019d1aab-f8ac-7ad3-9501-3ffbb8e404e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019d1aab-f8ac-7882-b44d-86c6e7fd888f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d1aab-f8ac-7b17-94f3-8cb1c209a099" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019d1aab-f8ac-7882-b44d-86c6e7fd888f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019d1aab-f8ac-7b4f-b83b-95d4bdcdc789" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d1aab-f8ac-7b17-94f3-8cb1c209a099" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019d1aab-f8ac-7b4f-b83b-95d4bdcdc789" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019d1aab-f8ac-79f2-8693-3c6267a90baa" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d1aab-f8ac-7b17-94f3-8cb1c209a099" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019d1aab-f8ac-79f2-8693-3c6267a90baa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019d1aab-f8ac-7061-99c4-cddc503aa7e7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d1aab-f8ac-7b17-94f3-8cb1c209a099" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019d1aab-f8ac-7061-99c4-cddc503aa7e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_019d1aab-f8ac-7cc1-bd8d-4a1f1723145c" xlink:href="gmed-20260331.xsd#gmed_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019d1aab-f8ac-7b17-94f3-8cb1c209a099" xlink:to="loc_gmed_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_019d1aab-f8ac-7cc1-bd8d-4a1f1723145c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019d1aab-f8ac-7f18-8277-bc0bd98ee548" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear_019d1aab-f8ac-7539-a5ae-7242c1de3299" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019d1aab-f8ac-7f18-8277-bc0bd98ee548" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear_019d1aab-f8ac-7539-a5ae-7242c1de3299" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_019d1aab-f8ac-70e0-8228-8781ae4439d5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019d1aab-f8ac-7f18-8277-bc0bd98ee548" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_019d1aab-f8ac-70e0-8228-8781ae4439d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_019d1aab-f8ac-7ba3-89f4-47a64558daab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019d1aab-f8ac-7f18-8277-bc0bd98ee548" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_019d1aab-f8ac-7ba3-89f4-47a64558daab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_019d1aab-f8ac-7722-b226-5062c7784bce" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019d1aab-f8ac-7f18-8277-bc0bd98ee548" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_019d1aab-f8ac-7722-b226-5062c7784bce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_019d1aab-f8ac-7d5d-ac2b-ad1cd0aef559" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019d1aab-f8ac-7f18-8277-bc0bd98ee548" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_019d1aab-f8ac-7d5d-ac2b-ad1cd0aef559" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_FinanceLeaseLiabilityToBePaidAfterYearFour_019d1aab-f8ac-77da-8e84-360f3ed83c30" xlink:href="gmed-20260331.xsd#gmed_FinanceLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019d1aab-f8ac-7f18-8277-bc0bd98ee548" xlink:to="loc_gmed_FinanceLeaseLiabilityToBePaidAfterYearFour_019d1aab-f8ac-77da-8e84-360f3ed83c30" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/LEASESScheduleofSupplementalCashFlowInformationDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#LEASESScheduleofSupplementalCashFlowInformationDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/LEASESScheduleofSupplementalCashFlowInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_gmed_TotalCashPaidForAmountsIncludedInMeasurementOfLeaseLiabilities_019d1aab-f8ac-7dcf-b3c3-c2c11a08d06f" xlink:href="gmed-20260331.xsd#gmed_TotalCashPaidForAmountsIncludedInMeasurementOfLeaseLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseInterestPaymentOnLiability_019d1aab-f8ac-7fef-a225-aedf1b73ae04" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseInterestPaymentOnLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_gmed_TotalCashPaidForAmountsIncludedInMeasurementOfLeaseLiabilities_019d1aab-f8ac-7dcf-b3c3-c2c11a08d06f" xlink:to="loc_us-gaap_FinanceLeaseInterestPaymentOnLiability_019d1aab-f8ac-7fef-a225-aedf1b73ae04" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeasePrincipalPayments_019d1aab-f8ac-79ed-90eb-196e552351a5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeasePrincipalPayments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_gmed_TotalCashPaidForAmountsIncludedInMeasurementOfLeaseLiabilities_019d1aab-f8ac-7dcf-b3c3-c2c11a08d06f" xlink:to="loc_us-gaap_FinanceLeasePrincipalPayments_019d1aab-f8ac-79ed-90eb-196e552351a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasePayments_019d1aab-f8ac-7f5a-b4c3-67b38fec20c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeasePayments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_gmed_TotalCashPaidForAmountsIncludedInMeasurementOfLeaseLiabilities_019d1aab-f8ac-7dcf-b3c3-c2c11a08d06f" xlink:to="loc_us-gaap_OperatingLeasePayments_019d1aab-f8ac-7f5a-b4c3-67b38fec20c6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.globusmedical.com/role/SEGMENTANDGEOGRAPHICINFORMATIONScheduleofTotalSegmentRevenueSignificantSegmentsExpensesandOtherExpensesDetails" xlink:type="simple" xlink:href="gmed-20260331.xsd#SEGMENTANDGEOGRAPHICINFORMATIONScheduleofTotalSegmentRevenueSignificantSegmentsExpensesandOtherExpensesDetails"/>
  <link:calculationLink xlink:role="http://www.globusmedical.com/role/SEGMENTANDGEOGRAPHICINFORMATIONScheduleofTotalSegmentRevenueSignificantSegmentsExpensesandOtherExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019d1b08-f833-7003-a11d-c945a0427d38" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-7180-8530-051aa0ad5c78" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019d1b08-f833-7003-a11d-c945a0427d38" xlink:to="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-7180-8530-051aa0ad5c78" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019d1b08-f833-7ee1-9001-1ace2a2eeeb9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019d1b08-f833-7003-a11d-c945a0427d38" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_019d1b08-f833-7ee1-9001-1ace2a2eeeb9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019d1b08-f833-7237-9ceb-2c4aab933010" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ForeignCurrencyTransactionGainLossBeforeTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019d1b08-f833-7003-a11d-c945a0427d38" xlink:to="loc_us-gaap_ForeignCurrencyTransactionGainLossBeforeTax_019d1b08-f833-7237-9ceb-2c4aab933010" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationBargainPurchaseGainRecognizedAmount_019d1b08-f833-734b-9ad7-93119a6a86d9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationBargainPurchaseGainRecognizedAmount"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_019d1b08-f833-7003-a11d-c945a0427d38" xlink:to="loc_us-gaap_BusinessCombinationBargainPurchaseGainRecognizedAmount_019d1b08-f833-734b-9ad7-93119a6a86d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProvisionForOtherLosses_019d1b08-f833-7fbf-a86d-66d656d9b6e8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProvisionForOtherLosses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:to="loc_us-gaap_ProvisionForOtherLosses_019d1b08-f833-7fbf-a86d-66d656d9b6e8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_019d1b08-f833-7977-b482-e26a89652f3b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_019d1b08-f833-7977-b482-e26a89652f3b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_019d1b08-f833-71b6-8cb2-733854165ef8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_BusinessCombinationAcquisitionRelatedCosts"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:to="loc_us-gaap_BusinessCombinationAcquisitionRelatedCosts_019d1b08-f833-71b6-8cb2-733854165ef8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSellingGeneralAndAdministrativeExpense_019d1b08-f833-7abd-ae61-fb2ce09692a3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherSellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:to="loc_us-gaap_OtherSellingGeneralAndAdministrativeExpense_019d1b08-f833-7abd-ae61-fb2ce09692a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LaborAndRelatedExpense_019d1b08-f833-730d-ae80-add856cdda54" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LaborAndRelatedExpense"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:to="loc_us-gaap_LaborAndRelatedExpense_019d1b08-f833-730d-ae80-add856cdda54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherResearchAndDevelopmentExpense_019d1b08-f833-7d21-978e-c265145f4136" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherResearchAndDevelopmentExpense"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:to="loc_us-gaap_OtherResearchAndDevelopmentExpense_019d1b08-f833-7d21-978e-c265145f4136" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSoldDepreciation_019d1b08-f833-7bd6-8f25-023f714f01af" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSoldDepreciation"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSoldDepreciation_019d1b08-f833-7bd6-8f25-023f714f01af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_019d1b08-f833-7d14-9642-c763b79ad964" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:to="loc_us-gaap_Revenues_019d1b08-f833-7d14-9642-c763b79ad964" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_ResearchAndDevelopmentEmployeeRelatedCosts_019d1b08-f833-7600-88c3-69ac2ff8c916" xlink:href="gmed-20260331.xsd#gmed_ResearchAndDevelopmentEmployeeRelatedCosts"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:to="loc_gmed_ResearchAndDevelopmentEmployeeRelatedCosts_019d1b08-f833-7600-88c3-69ac2ff8c916" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingOtherItemAmount_019d1b08-f833-7e70-a2bd-03a6650094cb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SegmentReportingOtherItemAmount"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:to="loc_us-gaap_SegmentReportingOtherItemAmount_019d1b08-f833-7e70-a2bd-03a6650094cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_gmed_AmortizationOfInventoryFairValueStepUp_019d1b08-f833-7770-a0ce-bc93783fe576" xlink:href="gmed-20260331.xsd#gmed_AmortizationOfInventoryFairValueStepUp"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:to="loc_gmed_AmortizationOfInventoryFairValueStepUp_019d1b08-f833-7770-a0ce-bc93783fe576" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_019d1b08-f833-7aa9-a849-e0db85584a3a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019d1b08-f833-790a-9f27-5ffae67dd3bd" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_019d1b08-f833-7aa9-a849-e0db85584a3a" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
